- 文献综述（或调研报告）：
炎症因子在冠心病检测中的作用
学生：平易 学号：42114108 指导老师：王莉娜
摘要：冠心病病理基础主要为动脉粥样硬化，同时血管慢性炎症硬化斑块、内皮细胞损伤、血液凝血等均参与了冠心病的发生与发展。既往研究表明，机体内炎症反应是引发机体冠状动脉粥样硬化的主要危险因素，因此炎症反应在冠心病的 发生发展中扮演了重要角色。C-反应蛋白(C-reactive protein，CRP)是一种典型的急性时相反应物，可用高灵敏度(Hs)法检测，是现今热门的冠心病生物标志物，已经被纳入初级预防的指导方针。其预测价值被发现独立于传统的心血管危险因素。对于以hs-CRP为代表的某些预防性治疗的生物标记物的监测可以降低炎症相关的冠心病的风险，可能有助于确定高危人群。
关键词：炎症因子、hs-CRP、冠心病
Abstract: The pathological basis of coronary heart disease is mainly atherosclerosis. At the same time, vascular chronic inflammatory plaques, endothelial cell injury, blood coagulation and so on are involved in the occurrence and development of coronary heart disease. Previous studies have shown that inflammatory response in the body is one of the main risk factors for coronary atherosclerosis, so inflammatory response plays an important role in the occurrence and development of coronary heart disease. C-reactive protein (CRP) is a typical acute phase reactant, which can be detected by high-sensitivity (Hs) method. It is a popular biomarker of coronary heart disease and has been included in the guidelines of primary prevention. Hypersensitive C-reactive protein can also be used to identify high-risk groups with significant recurrence events in patients with atherosclerosis. Its predictive value has been found to be independent of traditional cardiovascular risk factors. Monitoring of certain biomarkers for preventive treatment, such as hs-CRP, can reduce the risk of inflammation-related coronary heart disease and may help identify populations that will benefit from these interventions.
Key words: inflammatory biomarkers, hs-CRP, CAD
1 简介：
由动脉粥样硬化引起的冠状动脉疾病(CAD)是一种常见的心脏疾病，在临床上冠心病的发生可导致患者急性心肌梗塞或者心力衰竭，增加了患者短期内的死亡风险，具有较高的病死率[1]。流行病学研究显示，冠心病是世界范围内导致发病率和死亡率的主要原因。根据《中国心血管病报告2017》显示，我国心血管疾病死亡占城乡居民总死亡原因首位，农村为45.01%，城市为42.61%，城乡居民冠心病死亡率分别为110.67/10万、110.91/10万，且较上一年上升[2]。
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